Monday, July 11, 2005

Largest pharmaceutical study ever

Prof. Gerald Maguire pointed me towards Indevus' website. According to him, the company "is currently engaged in the largest pharmaceutical study ever on" PDS.

Here is the extract from the website:
"Pagoclone is a novel member of the cyclopyrrolone class of compounds and acts as a gamma amino butyric acid (GABA) receptor modulator. The Company believes that pagoclone increases the action of GABA, thus reducing excess neuronal activity and alleviating symptoms of anxiety.

We are currently evaluating the clinical and regulatory pathway to study pagoclone in stuttering, as well as the commercial opportunity in the U.S and in Europe. In the course of previous clinical trials for generalized anxiety disorder and panic disorder with pagoclone, we observed three patients who entered these trials with a secondary diagnosis of stuttering. These patients were noted to have a dramatic reduction in stuttering while receiving pagoclone. On discontinuation of study drug, stuttering returned to positive levels. These patients represented a small sample of the study and additional testing is necessary to determine whether pagoclone would be effective among a larger group of patients who stutter. A new method of use patent was recently granted to the Company in the U.S. covering the use of pagoclone as a therapeutic agent for stuttering.

We are contemplating initiating a Phase II study in stuttering during 2005 pending future evaluation of clinical, regulatory and commercial factors. Given the substantial preclinical, clinical, regulatory and manufacturing database that has been generated by us, our licensor, Aventis, and our former partners, Warner-Lambert and Pfizer, we believe pagoclone is a highly leveraged commercial opportunity. Should it be demonstrated to be safe and effective in stuttering, we believe we could form a specialty sales force that could successfully introduce the product to pediatric and adult neurologists in the U.S. We expect to seek a partner to commercialize the product outside the U.S.

Stuttering is defined as a break in the flow of speech which is disrupted by repetitions, prolongations or abnormal stoppages of sounds and syllables. It can be accompanied by unusual facial and body movements. Three million Americans suffer with stuttering, the cause of which is unknown. Currently, there is no approved pharmacotherapy for stuttering. The only approved treatment is speech therapy, encompassing physical, psychological and nutritional components." (Source Indevus, taken from their website on July 11th, 2005)

91 comments:

Josh said...

I appreciate your information on speech therapy. I just bookmarked your site and will be back regulalry to keep on top of it. Please check out my blog on speech therapy exposed - I'd really appreciate it

nuhad_abdallah@hotmail.com said...

I am suffring from stuttring I am ready to be one of the volunteers to try your medecine after the second phase trial I have ferforme RELAXATIO BIO FEEDBACK THERAPY CBT but with no success only XANAX helps me for a short time I am Ph.D Archetect 60 years

Anonymous said...

Tom, I am very interested in participating in a trial. I have looked at the selection criterion and I meet all the requirements. Where can I find information of a trial I could join? are there anyone in the U.S?
my email gabbiano7070@hotmail.com

Anonymous said...

i suffer from stuttering.. I´ll be willing to take the medicine... urgently.... i just want to know what can i do to buy pagoclone. my email adrees is salemmutiara@hotmail.com

cka1234 said...

I am a lifelong stutterer...I am in desparate need of relief...Therapy is a joke...If anything, it has made me worse...Pagoclone sounds like something I would love to try...When will it become available to the general public...If need be, I am willing to be a test subject inoder to have access to this drug...my email address is tomcarter1970@yahoo.com...Please let me know what is the status with pagoclone...

Anonymous said...

Two of my 3 children stutter and have since childhoon. My son is much worse than my daughter and can not speak on the phone at all. He is desperate for some type of help and this drup could be his lifesaver! Please let he know if there is a chance he could be in on one of the trials in the near future. My son is 26 and stuttering has really affected his self esteem. My email is lynda1198@aol.com

Anonymous said...

Can someone email me where i buy progolone form to online. I need it bad i am a stutter and hate it i have trouble talking in groups and even with friends please email me some info quick my email is redskin1845@yahoo.com

Buy Levitra said...

Great article! Thanks.

Phentermine said...

Thanks for interesting article.

Anonimous said...

Excellent website. Good work. Very useful. I will bookmark!

Anonymous said...

where i buy progolone zafaryousufi@yahoo.com

PaydayLoans said...

d3ZLOG You have a talant! Write more!

Auto insurance company said...

GgtbLh actually, that's brilliant. Thank you. I'm going to pass that on to a couple of people.

Hydrocodone said...

RJB8mp The best blog you have!

home loans for police officers said...

3OKLkE actually, that's brilliant. Thank you. I'm going to pass that on to a couple of people.

alyeska operations tour said...

Please write anything else!

buy cheap fioricet prescription said...

actually, that's brilliant. Thank you. I'm going to pass that on to a couple of people.

celebrex viox said...

actually, that's brilliant. Thank you. I'm going to pass that on to a couple of people.

xanax with out a script said...

Wonderful blog.

viagra said...

actually, that's brilliant. Thank you. I'm going to pass that on to a couple of people.

is tramado said...

Magnific!

xenical nasdaq said...

Please write anything else!

ingredient tramadol said...

Thanks to author.

JohnBraun said...

BF75wW write more, thanks.

comic books sex said...

Nice Article.

during pregnancy sex said...

Thanks to author.

animated sex gif said...

Hello all!

lean muscle sex said...

actually, that's brilliant. Thank you. I'm going to pass that on to a couple of people.

extreme anal streching said...

Magnific!

sex and getting said...

Please write anything else!

episcopalian same sex said...

Magnific!

pain with sex said...

Thanks to author.

bbc health sex said...

actually, that's brilliant. Thank you. I'm going to pass that on to a couple of people.

beastiality sex beastiality said...

Wonderful blog.

couples sex toys said...

Thanks to author.

horse sex download said...

Nice Article.

pussy and sex said...

Good job!

married sex dates said...

Ever notice how fast Windows runs? Neither did I.

night sex vision said...

Lottery: A tax on people who are bad at math.

doggie sex trailer said...

Please write anything else!

free lesbo porn mpegs said...

Change is inevitable, except from a vending machine.

bosnia sex trade said...

Clap on! , Clap off! clap@#&$NO CARRIER

bonded forced sex said...

Suicidal twin kills sister by mistake!

ala sex offenders said...

C++ should have been called B

japan car sex said...

actually, that's brilliant. Thank you. I'm going to pass that on to a couple of people.

hysteria over said...

A flashlight is a case for holding dead batteries.

cialis mix viagra said...

Wonderful blog.

order ultram said...

Suicidal twin kills sister by mistake!

iv leage sex said...

What is a free gift ? Aren't all gifts free?

belgium teen sex said...

Beam me aboard, Scotty..... Sure. Will a 2x10 do?

german public sex said...

Lottery: A tax on people who are bad at math.

as sex weapon said...

The gene pool could use a little chlorine.

all natual sex said...

The gene pool could use a little chlorine.

sex and tights said...

When there's a will, I want to be in it.

daddys friend sex said...

All generalizations are false, including this one.

nymphet sex favors said...

Give me ambiguity or give me something else.

clonidine patch tts2 said...

Suicidal twin kills sister by mistake!

name said...

A lot of people mistake a short memory for a clear conscience.

erotic stories hot juicy electric to said...

Lottery: A tax on people who are bad at math.

really free porn movies said...

Energizer Bunny Arrested! Charged with battery.

anime porn sites said...

When there's a will, I want to be in it.

lesbins having sex said...

Lottery: A tax on people who are bad at math.

asian young sex said...

Save the whales, collect the whole set

free video passwords porn said...

Please write anything else!

teen teen porn magazines for free said...

What is a free gift ? Aren't all gifts free?

hindi porn said...

Ever notice how fast Windows runs? Neither did I.

anal vid post said...

Build a watch in 179 easy steps - by C. Forsberg.

freeebony sex videos said...

Wonderful blog.

porn thunder pics said...

Oops. My brain just hit a bad sector.

having sex pamela said...

Hello all!

ice marijuana fl said...

Build a watch in 179 easy steps - by C. Forsberg.

celeb sex scens said...

The gene pool could use a little chlorine.

phone sex reviews said...

A lot of people mistake a short memory for a clear conscience.

brutus black sex said...

Clap on! , Clap off! clap@#&$NO CARRIER

casual sex parteners said...

Magnific!

fraudulent sex imigration said...

The gene pool could use a little chlorine.

huge pussy lips cunt shot porn said...

When there's a will, I want to be in it.

interracial sex wives said...

Clap on! , Clap off! clap@#&$NO CARRIER

welcome to xxxuploads the future of stre said...

Ever notice how fast Windows runs? Neither did I.

jos and sex said...

Give me ambiguity or give me something else.

position for sex said...

Calvin, we will not have an anatomically correct snowman!

big tits hardcore porn said...

Friends help you move. Real friends help you move bodies.

kuwait movie sex said...

The gene pool could use a little chlorine.

cartoon porn torrents movies said...

Clap on! , Clap off! clap@#&$NO CARRIER

12 volt sex said...

Give me ambiguity or give me something else.

party pool sex said...

A flashlight is a case for holding dead batteries.

buy cheap phentermine online phentermine pharmac said...

A flashlight is a case for holding dead batteries.

buy phentermine online ch said...

When there's a will, I want to be in it.

order phentermine overseas said...

Lottery: A tax on people who are bad at math.

illustrated sex 101 said...

Good job!

Anonymous said...

Good fill someone in on and this mail helped me alot in my college assignement. Thanks you as your information.