tag:blogger.com,1999:blog-12602489.post2200972939385972955..comments2024-03-24T15:07:18.773+01:00Comments on The Stuttering Brain: Research from IranTom Weidighttp://www.blogger.com/profile/02084153394215001999noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-12602489.post-30876636070586245882012-05-14T17:50:28.460+02:002012-05-14T17:50:28.460+02:00and of course, no response to your comment. surpri...and of course, no response to your comment. surprise.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-12602489.post-50751155745853641632010-01-05T23:29:53.770+01:002010-01-05T23:29:53.770+01:00This is not true for all PWS. I have tried both Z...This is not true for all PWS. I have tried both Zyprexa Zydis and Pagaclone with no fluency gains and severe side effects (Zyprexa). Even if dopamine antagonist medication helps some, the basal ganglia excitation is not the sole culprit. Don't forget the left hemisphere white matter density deficit and right hemisphere compensation (in low stress situations of cooouuurse).ig88sirhttps://www.blogger.com/profile/14118519918762348922noreply@blogger.comtag:blogger.com,1999:blog-12602489.post-9357875467816809852008-03-18T21:31:00.000+01:002008-03-18T21:31:00.000+01:00The Iran research fits right into the "excessive d...The Iran research fits right into the "excessive dopaminergic activity" theory of stuttering advanced my Dr. Gerald Maguire and others (including me: http://members.aol.com/rharkn/).<BR/>There are several pages on the brain basis of stuttering there. I've also elucidated step-by-step the pathway from the brain's striatum (caudate/putamen) to the motor cortex, showing how GABA-receptor stimulation ultimately decreases dopaminergic activity and thus decreases motor cortex excitation. This is how Pagoclone, the selective GABA-agonist "anti-stuttering" drug wending its way through the FDA approval process, works. Excessive dopaminergic activity increases what I've termed "excitation feedback," which is discussed in detail on the above-mentioned Web site. I plan to post more about this on the site soon.<BR/><BR/>Best regards, Richard H.Richard H.https://www.blogger.com/profile/10250119179053735063noreply@blogger.com